Abstract
The present research work support preformulation, formulation, development and optimization of colon targeted microsponges containing Celecoxib as a nonsteroidal anti-inflammatory drug. The different batches of formulation were evaluated using celecoxib as active pharmaceutical ingredient, Eudragit as the pH sensitive polymer, polyvinyl alcohol and triethyl Citrate. Colon targeted microsponges of Celecoxib were prepared by Quasi-emulsion solvent diffusion method. The prepared formulations were evaluated for various parameters like Particle size, Percentage entrapment efficiency, Measurement of Zeta Potential, FTIR, in-vitro release study. The result were found to be within standard limits. FTIR study reports indicated that there was no interaction between Celecoxib and other excipients. Zeta Sizer shown that the microsponge size ranges from 61.12 μm to 67.59μm. Percent drug content was between 65.18%– 95.19%. Based on the resultants of the entrapment and particle size of microsponges, formulation M4 was observed to be optimized formulation. The optimized formulation exhibited 71.52% cumulative drug release after 10 h. The optimized batch shows 77.40% yield.
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