Abstract
Objective: The present formulation was developed with the intention to formulate versatile 5-fluorouracil (5-FU) mucoadhesive tablet that fulfill the therapeutic need that is lacking in current cancer treatment and aimed at minimizing toxic effect, enhancing efficacy and increasing patient compliance. Method: Mucoadhesive tablets of 5-fluorouracil were prepared by direct compression technique using different grades of polymer with varying concentration. The tablets were compressed using 10 mm flat faced punch on a single stroke-punching machine. The formulations were tested for drug content, hardness, friability, weight variation, thickness, swelling studies, in vitro drug release, ex vivo permeation studies, mucoadhesive strength. Result and Discussion: The formulated mucoadhesive buccal tablet was evaluated for various parameter and formulation F7 was found as the optimum batch. Conclusion: From the above study it was concluded that Formulation F7 was found optimized formulation showing optimum results for all the evaluated parameters. The drug content was 98.75%, swelling index 130 at 6 hours, Mucoadhesive Strength 22.1 and force (N) 0.216801, Residence time was more than 8hours and drug release was found to be 96.78%.
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