Formulation and development of herbal microsponge sunscreen gel.

Abstract

The endeavor of this study is to prepare and developed a method for microsponge gel as a polyherbal formulation along with their evaluation methods for sunscreen properties. Polyherbal extracts as an active component for preparing microsponge formulation used in ratio of a drug, i.e. Poly herbal extracts, ethyl cellulose used as polymer, Polyvinyl alcohol as an emulsifier present in the formulation was successfully obtained by using method quasi-emulsion solvent diffusion. The formulations prepared were considered for substantial characterization. The physical description of microsponge formulation, having a coating of Gel-3 exhibits more loading efficiency and production yield. The mentioned formulation of microsponge was formulated with the help of gel using carbopol and then test performed are pH, viscosity, spreadability, drug content, and in-vitro release. Most of the microsponge preparations are prepared by drug loading in it and the consequences are good to reproduce. The best formulation was prepared and then comparison study was done with one of the marketed simple gel of polyherbal extract and other one is microsponge loaded gel of polyherbal extract by using Franz diffusion cell. The release profile details about that the microsponge loaded gels are showing excellent release rate while comparing to simple marketed gel of polyherbal extract.