Formulation and Comparative Evaluation of Transdermal Patch and Proniosomal Gel of Ropinirole, An Anti-Parkinson’s Drug

Abstract

The conventional multidose antiparkinson’s therapy leads to re-emergence of Parkinson’s symptoms, due to fluctuations in serum levels of drug. Ropinirole HCl is a drug used to treat Parkinson’s disorder and it is suitable drug candidate for transdermal delivery due to its small molecular size, optimum log P and low oral bioavailability due to first pass metabolism. The combination of Different HPMC grades with PVP K 30 was used to formulate transdermal matrix by solvent Evaporation Method. A 32 full factorial design was used for optimization in which grade of HPMC (X1), % concentration of PVP K30 (X2) were selected as independent variables while t90% was taken as dependent variables. Further Proniosomal gel was also formulated using coacervation phase separation method. Formulated transdermal patch was evaluated for their folding endurance, tensile strength and t90%. Proniosomal gel was evaluated for their vesicle size, morphological analysis was done by Scanning Electron Microscopy. Both transdermal patch and Proniosomal gel were compared for their Flux, t90 %,CombinationofHPMC K 100M with PVP K30 Showed Highest drug retention which was confirmed by stastical analysis using factorial design. Gel formulation with Span 60 showed good polydispersitivity with particle size distribution of 0.497 µm. comparative flux showed that Proniosomes have better flux on other hand transdermal patch are retaining drug for more time.Present work showed possibility to formulatetransdermal patch and proniosomal Gel to attain desired release of Ropinirole HCL up to 24hr. It is possible to use different blend of HPMC and PVP K30, Proniosomal gel can also be used for sustain release of drug with sufficient lipophilic characters