Formulation and characterization transdermal patches with chitosan-alginate of mangosteen peel (garcinia mangostana l.)

Abstract

Mangosteen peel extract contains xanthones have an anti-inflammatory effect and accelerated the process of fibroblast proliferation. The xanthones would trigger the formation of collagen which plays an important role in the wound healing process. The preparation of mangosteen peel extract into the trans-dermal patch aims to deliver the active substances through the skin and to the systemic system painlessly. The aims of this research were to formulate and characterize patch trans-dermal mangosteen peel extract. The formulation was characterized by organoleptic, uniformity of thickness and weight, folding resistance, pH, moisture content, drug content, swelling, in vitro drug release test, FTIR spectrum, and morphology by SEM. The patch trans-dermal was prepared using chitosan and sodium alginate by layer by layer using 0,2%, 0,4%, and 0,6�lcium chloride as crosslinker. The enhancement in the concentration of calcium chloride had a significant effect (p<0>300 folds, pH of 5, moisture content of 1,84%, swelling degree value of 3,41%, and penetration test results were found with a percent penetration of 38,87%. The results of the morphological obtained a pore size of 5,88 μm. The results of the FTIR spectrum showed that there was interaction by the presence of a new peak at the wave number of 1622,23 cm-1. It can be concluded that calcium chloride in patch trans-dermal affected physical properties and in vitro drug release of mangosteen peel extract.