Formulation and characterization of solid lipid nanoparticles containing Camptotheca acuminata extract for the treatment of pancreatic cancer

Abstract

To this day, pancreatic cancer remains not only one of the deadliest but also one of the most challenging types of the disease to successfully treat. Innovative therapy approaches are necessary if they are to be utilised in order to improve patient outcomes. The formulation and characterization of solid lipid nanoparticles (SLNs), which are intended for the targeted therapy of pancreatic cancer, are the primary objectives of this research. The solid lipid nanoparticles include an extract from Camptotheca acuminata, which has the possible ability to act as a natural anticancer drug. The goal of this research project is to enhance the therapeutic efficacy of an extract derived from Camptotheca acuminata by concentrating on the development of SLNs as a technique for the administration of drugs. SLNs have improved drug solubility, a longer period in circulation, and higher cellular absorption.