Formulation and characterization of solid lipid nanoparticles loaded Neem oil for topical treatment of acne

Abstract

ObjectiveTo investigate the treatment of acne and pimples as well as improves skin elasticity by solid lipid nanoparticles (SLNs) loaded Neem oil. MethodNeem oil as a natural agent was incorporated into SLNs prepared by double emulsification method using different concentration of lecithin and Tween 80. The characteristics of SLNs with different concentration of lipid were investigated. ResultsThe average particle size of Neem oil loaded SLNs decreased with increasing concentration of surfactant. SLNs of (221.6 ± 2.0) nm with a Polydispersity index of (0.948 ± 0.040) were obtained at higher concentration of lipid and surfactant. High entrapment efficiency of 82.10% revealed the ability of solid lipid nanoparticles to incorporate a high quantity of Neem oil. Furthermore the stability of SLNs indicated with negligible drug leakage after 3 weeks. ConclusionThe result concluded that Neem oil loaded solid lipid nanoparticles with more lecithin content in their colloid exhibit sustained effect which satisfactorily produced the antibacterial action on Acne microbes. Therefore Neem oil loaded SLN was used successfully for prolonged treatment of Acne.