Formulation and Characterization of Novel Micrpoarticles of Hydrochlorothiazide by Solvent Evaporation Technique

Abstract

Microparticles are defined as particulate dispersions or solid particles with a size in the range of 1-1000 µm. The drug is dissolved, entrapped, encapsulated or attached to a Microparticle matrix. Depending upon the method of preparation, Microparticles, microspheres or microcapsules can be obtained. In the present study the Solid Dispersion of Hydrochlorothiazide obtained from Solvent Evaporation technique was formulated in the Microparticulate drug delivery for the sustaining the release rate. The present study involves formulation and development of Microparticles of Hydrochlorothiazide by Ionic Gelation and Coacervation Phase Separation technology. These two techniques showed compatibility of process and polymers. Studies have indicated that Hydrochlorothiazide loading affected the Hydrochlorothiazide release kinetics/mechanism from Microparticles. The microparticles prepared by Coacervation Phase Separation of Ethyl Cellulose and Eudragit RL-100 binary mixtureshowed controlled release of Hydrochlorothiazide in-vitro and were found to be most stable. No significant effects of drug loading on the Microparticle size, morphology, and size distribution were observed. Kewords:-Solubility enhancement, microparticles, solvent evaporation,Hydrochlorothiazide