Formulation and characterization of mouth dissolving films loaded with solid dispersion of griseofulvin

Abstract

The main objective of the present work was to formulate mouth dissolving films containing griesofulvin solid dispersion to attain its maximum drug release with a very short time and also to have an easy and compliant administration of the drug through oral route. β-cyclodextrin was used to prepare solid dispersion in the ratio 1:1 for drug and polymer by solvent evaporation method. The solid dispersion was obtained in yield of approximately 96% suggesting completion recovery of the dissolved material. Pure griseofulvin was found to exhibit a solubility of 62.0 µg/mL after 24 hours whereas the solid dispersion exhibited a significant increase in solubility showing a solubility of 570 µg/mL. All the formulated batches exhibited quick drug release, rapid disintegration and optimal mechanical strength. The formulations neither exhibited much loss nor much uptake of moisture as observed from the results of the study. The folding endurance was found to increase with increasing concentration of the plasticizer whereas thickness was found to be related to the amount of the polymer in the formulation.