Abstract
Currently, a large number of populations are suffering from diabetes mellitus, which significantly increases the burden on public health. Glimepiride is an antidiabetic drug with a shorter half-life (approximately 5 hours), low bioavailability, and first-pass metabolism. Due to these limitations, it is required to maintain a uniform therapeutic level, and it has been chosen as a transdermal drug delivery approach. The main objective of this investigation was to evaluate glimepiride-loaded transdermal patches on the skin to treat diabetes mellitus. To overcome the issue of oral glimepiride and provide a localized effect, a transdermal drug delivery approach was developed. The glimepiride transdermal drug delivery approach was developed by using the solvent evaporation method. To examine the impact of altering amounts of polyvinyl alcohol (X1) and polyvinyl pyrrolidone (X2) on tensile strength, % of glimepiride released in 12 hours (Q12), and % of glimepiride released in 24 hours (Q24), as reliant on variables, a 32 complete factorial design was employed. For dependent variables, regression estimation and estimation of variance were employed. In-vitro release statistics were fixed to different models for various glimepiride release kinetics. In-vitro glimepiride release was tested using the best formulation. The formulation F4 with 1300.00 milligrams of polyvinyl alcohol and 600.00 milligrams of polyvinyl pyrrolidone demonstrated a release of 96.17% for up to 24 hours and zero order release kinetics consisting of r2=0.987, which was the best batch. The optimized formulation F4 showed a controlled release of glimepiride and better permeation and deposition properties. The findings of this research work demonstrated the potential of the 32 full factorial mathematical models created to anticipate formulations with additional desirable release and permeability qualities for the treatment of diabetes mellitus.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have