Abstract
Formulation & Evaluation of Sustained Release Matrix Tablet of Repaglinide
Highlights
Among the innumerable methods used for sustained release formulation matrix is the most popular approach
Repaglinide sustained release matrix tablets were successfully prepared by using various grades of Hydroxy Propyl Methyl Cellulose (HPMC) as polymer to retard the release and achieve the retard dissolution profile
Drug & polymer were found to be compatible as indicated by FTIR studies & differential scanning calorimeter (DSC) thermogram
Summary
Among the innumerable methods used for sustained release formulation matrix is the most popular approach. Hydrophilic polymers are most widely used in matrix system because these are cost effective, make it easy to achieve desirable drug profile & have broader FDA acceptance. Repaglinide is an effective antihyperglycemic used for the management of Type 2 Diabetes Mellitus. It is a benzoic acid derivative belonging to meglitinide class of oral hypoglycemic. After oral administration it is rapidly & completely absorbed & peak plasma concentration is achieved in approximately 1hr. In present study an attempt has been made to formulate sustained release matrix tablet of repaglinide & to evaluate the same for various parameters; in order to produce additional antidiabetic activity thereby resulting in dose reduction & its dose related side effects
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