Formulasi Sediaan Salep Ekstrak Minyak Atsiri Daun Jeruk Purut (Citrus Hystrix DC.) terhadap Jamur Candida Albicans

Abstract

<p><em>T</em><em>he purpose of this</em><em> study </em><em>was</em><em> to formulate essential oils in ointment preparations with different bases and to determine the physical properties and antifungal activity against Candida albicans.</em><em> </em><em>The essential oil of kaffir lime leaves was obtained by distillation using the water distillation method and the raw material of fresh kaffir lime leaves was 1.5 k</em><em>ilograms</em><em> which was then identified with Sudan III reagent and formulated in ointment preparations.</em><em> </em><em>The ointment is made with FI, FII, and FIII base formulations with an active substance concentration of 7%. The FIII ointment base had the best evaluation results and was continued for antifungal testing against Candida albicans.</em><em> </em><em>From the research results obtained % yield of essential oil of kaffir lime leaves is 1.533%. The results of the phytochemical identification test showed positive results with the formation of an even red color in the solution.</em><em> </em><em>The results of the evaluation of the ointment preparations showed that FIII had the best evaluation results and continued antifungal testing with a positive control of 2% miconazole nitrate cream.</em><em> </em><em>The average diameter obtained is 8.43 mm and is included in the medium category.</em><em> </em><em>The results of the Shapiro Wilk normality test showed that the research data was normally distributed and homogeneous, then the One-Way ANOVA test was carried out and a significance value of P<0.05 was obtained, and the LSD test showed a significant difference seen from the significance value obtained P<0.05.</em><em></em></p><p><em> </em></p>