Abstract
The GlcNAc-specific lectin from Solanum tuberosum is shown to induce haptenic-sugar-resistant contacts in platelet aggregation but not to induce stable neutrophil and lymphocyte aggregation. The formation of such contacts in platelets was significantly hindered by the inhibitors of cAMP phosphodiesterase (papaverine) or arachidonic acid metabolism (indomethacin, aristolochic acid, or MK-886) and by a sulfhydryl reagent (N-ethylmaleimide). This lectin can be useful in studying the mechanisms of stable platelet aggregation, drug screening for antithrombotic activity, and developing the cell engineering techniques.
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