Abstract
S-Adenosylethionine was prepared from the livers of rats fed a basal diet containing 0.2% dl-ethionine, and was identified by Chromatographic, spectrophotometric, chemical, and isotope recovery procedures. The hepatic levels of adenosine triphosphate (ATP), guanosine triphosphate (GTP), and uridine triphosphate (UTP) in rats fed the ethionine diet for either 5 or 20 weeks were markedly diminished; they averaged 0.3–0.4 the values of control rats fed the same basal diet without ethionine. The hepatic level of adenosine monophosphate (AMP) in the ethionine-fed rats was 1.4 times that of the control animals at both time periods. The level of adenosine diphosphate (ADP) in the livers of rats fed ethionine was comparable with that of the control group at 5 weeks, but was only half that of the control group at 20 weeks. The hepatic levels of AMP, ADP, and ATP in rats injected with ethionine were lower than those of the control group, ATP being affected to the greatest extent. Accumulation of S-adenosylethionine in the livers of ethionine-injected rats could account for more than 85% of the decrease in adenosine phosphate compounds.
Published Version
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