Abstract
Cytochemical and fluorescent antibody techniques have been utilized to study the release of poliovirus. Electron microscopic studies of ultrathin sections of epoxyembedded monkey kidney cells infected with poliovirus (types 1 and 2 virulent and attenuated) have revealed cytoplasmic arrays of spherical particles each approximately 25 mμ in diameter. Similar particles were found occasionally in “blebs” at the plasma membrane. Particles were detected only when infected cultures were incubated at 30°C. At this temperature fully infective poliovirus is formed but its release is inhibited. Particles were not encountered in infected cultures incubated at 37° or in control preparations.
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