Abstract
The pineal hydroxyindole- O-methyl transferase (HIOMT) catalysed formation of N-acetyl-3,4-dimethoxyphenethylamine (NADMPEA) from both N-acetyl-4-hydroxy-3-methoxyphenethylamine and N-acetyl-3-hydroxy-4-methoxyphenethylamine have been demonstrated in vitro. Dimethylation was not achieved. The formation of NADMPEA is shown also to be inhibited by haloperidol. It is suggested that, in schizophrenia, pineal HIOMT might get out of phase with its normal substrate and so act on other substrates, thus producing abnormally methylated catecholamine derivatives.
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