Abstract
Pyridoxal-5′-phosphate (PLP) in vitro was found to inhibit strongly the conversion of N-acetylserotonin to melatonin by hindering the pineal hydroxyindole- O-methyl transferase (HIOMT) activity. This inhibition was competitive with respect to the methyl donor S-adenosylmethionine but non-competitive as regards the substrate N-acetylserotonin. Noradrenaline, which had no effect on HIOMT activity, almost completely abolished the inhibitory effect of PLP on that enzyme.
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