Abstract
AbstractBase‐induced coupling/cyclization stepwise [3+2] annulation of α‐sulfonylacetamide with (Z)‐2‐bromoacrylates yielded polysubstituted pyroglutamates with three contiguous chiral centers with trans‐trans orientation in a one‐pot synthesis. The pyrrolizidine skeleton was obtained via an intramolecular cyclization. This facile strategy was used to synthesize (±)‐trachelanthamidine.
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