Formal synthesis of 10‐Hydroxy‐6‐Aryldibenzo[b,g][1,8]Naphthyridin‐11(6H)‐ones from 2‐chloroquinolin‐3‐carbaldehydes and 3‐(Arylamino)cyclohexenones

Abstract

AbstractWe have described herein a simple and formal synthesis of 10‐Hydroxy‐6‐Aryldibenzo[b,g][1,8]naphthyridin‐11(6H)‐ones from 2‐chloroquinolin‐3‐carbaldehydes and 3‐(Arylamino)cyclohexenones. This protocol provides the formation of four rings including 1,8‐naphthyridin under the mild conditions. Furthermore, the cyclohexanone part of the enaminone undergoes air oxidation provided the phenol ring is attached directly to the 1,8‐naphthyridin scaffold. These newly formed chemo‐types may be useful in drug discovery programs probably as antibacterial agents due to the presence of 1,8‐naphthyridine.