Forearm blood flow response to acute exercise in obese and non-obese males

Abstract

Chronic exercise is thought to improve endothelium-dependent vasodilation; however, few studies have evaluated the effects of acute exercise on microvascular vasodilatory capacity (MVC). Moreover, no studies have compared MVC responses in obese and non-obese individuals following acute exercise. To evaluate MVC, utilizing forearm blood flow (FBF) and excess blood flow (EBF) before and up to 48 h after a single exercise bout to elicit peak oxygen consumption (VO2 peak) in obese and non-obese males. Twelve obese (37.0 ± 1.1 kg/m(2)) and 12 non-obese (21.9 ± 0.3 kg/m(2)) males volunteered to participate. FBF measures, before and during reactive hyperemia (RH), were obtained prior to (PRE-E), immediately after (POST-E), and at 1 (POST-1), 2 (POST-2), 24 (POST-24), and 48 (POST-48) hours after exercise. EBF, was calculated as the difference between FBF, before and during RH. Blood samples were obtained to evaluate the response of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α), which are potential modifiers of MVC. FBF before and during RH were significantly (P < 0.05) increased in both groups POST-E. The EBF magnitude of change from PRE-E was significantly (P < 0.05) elevated in non-obese when compared with obese males. Although not related to MVC, concentrations of IL-6 significantly decreased between POST-2 and POST-24 in both groups. An acute bout of exercise designed to elicit VO2 peak significantly increased forearm MVC in non-obese and obese males, although the magnitude of change in EBF from PRE-E to POST-E was greater in non-obese males.