FONKSİYONEL DİSPEPSİLİ HASTALARDA HELİKOBAKTER PİLORİ ERADİKASYONUNUN SERUM OKSİDE LDL DÜZEYLERİ ÜZERİNE ETKİLERİ

Abstract

Objectives: Since its discovery, Helicobacter pylori (H. pylori) have been implicated in the pathogenesis of several diseases located both in the digestive and extradigestive systems. Interestingly, the majority of the literature on extradigestive-related disease mainly focuses on ischemic heart disease. Oxidized low-density lipoprotein (ox-LDL) is an important key point in the progression of atherogenesis. The aim of the present study was to investigate whether the eradication of H. pylori infection affects serum ox-LDL levels. Methods: A total of 73 patients with H. Pylori–associated dyspepsia and 23 controls were included in this study. Bismuth quadruple therapy was given for 14 days. Serum levels of ox-LDL, LDL and high-density lipoprotein (HDL) were measured at baseline and 8 weeks after therapy. Successful eradication was proven with the 14C-urea breath test.Results: There were no significant differences in terms of age and gender between the patients and controls (p=0.066 and p = 0.475, respectively). Comparing H. Pylori patients to healthy controls with respect to serum ox-LDL and LDL levels were significantly higher in the patient group (p=0.04 and p=0.046 respectively). It was noticed that oxLDL levels were lower in eradicated patients with no correctable risk factors for cardiovascular disease after therapy (p=0.047). However, there was no statistically significant difference in serum ox-LDL levels between baseline and after therapy among the other patients (p>0.05). Conclusion: The findings of our study might indicate that H. pylori eradication influences the oxidation of LDL. However, the role of H. pylori infection on atherosclerosis progression is a controversial issue.