Abstract TMP94: Oxidized Low-Density Lipoprotein and Low-Density Lipoprotein Have Combined Utility in Predicting Outcomes of Minor Stroke and TIA

Abstract

Objective: To estimate the association of different combination of circulating LDL and oxLDL levels with the outcomes of acute minor ischemic stroke and transient ischemic attack (TIA). Methods: In the Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events (CHANCE) trial, a subgroup of 3019 patients with elevated baseline oxLDL and LDL levels were analyzed. Patients were divided into four groups according to different combination of LDL and oxLDL levels. The associations of LDL and oxLDL with prognosis of patients using multivariable Cox regression models. Results: Among 3019 patients included in this study, the median (interquartile range) of oxLDL, and LDL were 13.96 (6.65-28.81) ug/dL, 3.1(2.5-3.8) mmol/L, respectively. Compared with those with low LDL and oxLDL levels (LDL < 3.37mmol/L with oxLDL <13.96 ug/dL), patients with conformably high levels of LDL and oxLDL (LDL ≥3.37mmol/L , oxLDL ≥13.96 ug/dL) were associated with an increased risk of recurrent stroke at 90 days(HR,1.88; 95% CI,1.37-2.57)) and 1 year (HR,1.71; 95% CI,1.29-2.27). Neither elevated level of oxLDL or LDL increased alone showed statistical significance. Similar results were observed for poor functional outcome. Conclusions: Presence of both elevated oxLDL and LDL levels can predict an increased risk of recurrent stroke and poor functional outcome in minor stroke or high- risk TIA patients. The presence of both oxLDL and LDL might have a combined effect.