Abstract
Systemic lupus erythematosus (SLE) is a severe systemic autoimmune disease, which is characterized by excessive production of autoantibodies caused by B cell hyperactivity. Thus, reducing autoantibody production can control the development of SLE, and understanding the molecular and cellular factors involved in the differentiation of B cells will provide new therapeutic targets. Follicular helper T cells (Tfh) are defined as a new subset of CD4+ T cells specialized in providing help to B cells, which is suspected to play a critical role in the pathogenesis of SLE. In the present review, we give an overview of key molecules involved in the differentiation, regulation and functions of Tfh, discuss the roles of Tfh in SLE and describe some potential therapeutic targets for SLE. Key words: Systemic lupus erythematosus; Follicular helper T cell; Pathogenesis; Therapy
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