Folate-receptor 1 level in periodontal disease: a pilot study

Duygu Alkan,Umut Balli,Murat Can,Cigdem Coskun Turer,Berrak Guven

doi:10.1186/s12903-019-0909-z

Abstract

BackgroundThe purpose of this study was to investigate gingival crevicular fluid (GCF) and serum folate-receptor 1 (FOLR1) levels in subjects with different periodontal status.MethodsThe study consists of three groups: Healthy group (n = 15), gingivitis group (n = 15) and chronic periodontitis group (n = 15). Clinical periodontal parameters including probing pocket depth (PPD), clinical attachment level (CAL), gingival index (GI) and bleeding on probing (BOP) were assessed. GCF and serum samples were collected from each patient and were analyzed FOLR1 levels by enzyme-linked immunosorbent assay.ResultsThe values of FOLR1 in GCF were higher in gingivitis and periodontitis groups than among patient in control group (p < 0.016). Serum FOLR1 levels showed no significant difference between the groups. A significant correlation was observed between FOLR1 levels of GCF and BOP (p < 0.05).ConclusionsOur preliminary data suggest that FOLR1 is not useful in monitoring the periodontal disease. Further studies are necessary to clarify the role, regulation and function of folate and it’s receptors in the pathogenesis of periodontal disease.

Highlights

The purpose of this study was to investigate gingival crevicular fluid (GCF) and serum folate-receptor 1 (FOLR1) levels in subjects with different periodontal status
FOLR1 levels were assayed by Human FOLR1 kit (Boster, CA, USA) using enzyme-linked immune sorbent assay (ELISA) method
There was no significant difference in serum FOLR1 concentration between patients and healthy controls (0.05 > p)

Summary

Introduction

The purpose of this study was to investigate gingival crevicular fluid (GCF) and serum folate-receptor 1 (FOLR1) levels in subjects with different periodontal status. Periodontal disease is an inflammatory disorder affecting the tooth-supporting tissues which they consists of two types of tissues - epithelial and connective tissue. The tooth-supporting tissues includes the alveolar bone, the periodontal ligament, the cementum, and the gingiva. Gingivitis is a form of periodontal disease in which gingival tissues are inflamed but their destruction is mild and reversible. Periodontitis is a chronic inflammatory status may leading with irreversible changes, such as bone and teeth loss [1]. Recent studies have suggested that there may be an association between oral health status and nutritional status. Especially micronutrients contain various vitamins that they are required for oral health maintaining [3, 4]

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