Focus on "Sodium 4-phenylbutyrate downregulates Hsc70: implications for intracellular trafficking of DeltaF508-CFTR".

Abstract

the ability of newly synthesized proteins, particularly oligomeric or multidomain proteins, to fold into unique, three-dimensional structures in vivo is dependent on their amino acid sequence and the activities of enzymes and molecular chaperone proteins that catalyze folding ([9][1]). Evidence is