Abstract
In the final issue for 2003 of the STKE series on protein interaction domains, Science's STKE focuses on domains implicated in protein trafficking and those that permit protein interaction with membranes. Cell function depends not only on the appropriate expression of proteins, but also on their acting in the right place at the right time. Proper transport of proteins is essential for delivery of proteins to their sites of action as well as for terminating their activity or for rerouting of proteins, which may allow them to gain access to different interacting partners. Protein interactions with membranes, especially through binding to phosphoinositide lipids, provide a mechanism for temporal and spatial regulation of protein activity in response to signals that alter the abundance of these phosphorylated lipids. Similarly, protein interaction domains created through posttranslational modifications allow cell signals to govern the spatial and temporal localization of protein-protein interactions.
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