Abstract
32.1 MECHANISMS OF ABNORMAL POSTTRANSLATIONAL PROTEIN PROCESSING IN SCHIZOPHRENIA BRAIN
Highlights
Molecular disturbances of neurotransmitter systems have long been held to be a core feature of the pathophysiology of schizophrenia
Previous studies have shown the important roles posttranslational lipid and carbohydrate modifications play in targeting receptors, transporters, and other proteins between intracellular compartments and the synapse, and in the lateral translocation of such molecules between lipid microdomains at the distal end of forward trafficking pathways
We have previously reported changes in extent of N-linked glycosylation as well as of the lipid modifications palmitoylation and N-myristoylation on target proteins in schizophrenia brain
Summary
Molecular disturbances of neurotransmitter systems have long been held to be a core feature of the pathophysiology of schizophrenia. 32.1 MECHANISMS OF ABNORMAL POSTTRANSLATIONAL PROTEIN PROCESSING IN SCHIZOPHRENIA BRAIN Despite years of study of neurotransmitter associated protein expression at multiple levels of gene expression, reports of abnormal neurotransmitter receptor transcript, protein, and signaling complex expression in schizophrenia brain have often been conflicting.
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