Abstract
Foamed polycaprolactone impregnated with quercetin was carried out with a batch foaming technique using supercritical CO2. The experimental design was developed to study the influence of pressure (15–30 MPa), temperature (308–333 K), and depressurization rate (0.1–20) on the foam structure, melting temperature, and release tests of composites. The characterization of the experiments was carried out using scanning electron microscopy, X-ray diffractometer, and differential scanning calorimetry techniques. It was observed that the porosity created in the polymer had a heterogeneous structure, as well as the impregnation of the quercetin during the process. On the other hand, controlled release tests showed a significant delay in the release of quercetin compared to commercial quercetin.
Highlights
The use of CO2 as a blowing agent in foaming has become increasingly popular in the scientific community to encapsulate, fabricate scaffolds, and produce delivery-controlled systems
This paper focused on the use of a biodegradable polymer PCL as a coating agent for a delivery system to control the release of an active substance
D8 Advance diffractometer in order to determine the amorphous or crystalline nature of the loaded with quercetin after to determine the amorphous or crystalline nature of the foamed polymer loaded with quercetin the supercritical foaming/impregnation process
Summary
The use of CO2 as a blowing agent in foaming has become increasingly popular in the scientific community to encapsulate, fabricate scaffolds, and produce delivery-controlled systems. In the case of the effect caused by swelling in the matrix, this leads the polymer chains to reorganize into a more extended configuration All this causes a greater facility in the formation of crystalline structures and, it usually decreases the melting temperature [7]. This flavonoid is highlighted for its antioxidant action, but it has different benefits such as anti-inflammatory, antibacterial, cardiovascular health, and anticancer effects [21,22] This antioxidant compound has been used by several authors with scCO2 in addition to different supercritical techniques, such as a supercritical antisolvent process to co-precipitate or encapsulate the quercetin with polymer [23,24] and a supercritical impregnation process (SSI) to impregnate the quercetin into different polymers or a porous matrix [25,26]. The effect of pressure, temperature, and depressurization rate on the foaming process, the melting temperature and melting heat of the composites, and on the release profiles of quercetin were evaluated
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