Abstract
FMRP: a triple threat to PSD-95
Highlights
Autism is a spectrum of developmental disorders characterized by deficits in verbal and non-verbal communication, social awareness and interactions, and imaginative play (Caronna et al, 2008)
postsynaptic density (PSD)-95 synthesis at synapses is regulated through group 1 metabotropic glutamate receptors, FMRP, and microRNA-125a (Todd et al, 2003; Muddashetty et al, 2012)
The myocyte enhancer factor 2 (MEF2) proteins bind to synaptic activity-responsive elements (SARE), which are significantly enriched in genes that encode mRNAs targeted by FMRP (Rodríguez-Tornos et al, 2013)
Summary
Autism is a spectrum of developmental disorders characterized by deficits in verbal and non-verbal communication, social awareness and interactions, and imaginative play (Caronna et al, 2008). A commentary on Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95 by Tsai, N.-P., Wilkerson, J. In their Cell article, Tsai and colleagues provide a mechanistic framework explaining how multiple autism-related genes cooperate in experience-dependent synapse elimination and how that mechanism fails in FXS (Tsai et al, 2012).
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