Abstract
Fluoroquinolone restriction to control fluoroquinolone-resistant Clostridium difficile
Highlights
Between 1989 and 1992, an epidemic strain of Clostridium difficile that was highly resistant to clindamycin emerged and caused outbreaks of C difficile infection in several locations in the USA.[1]
Use of clindamycin was identified as a specific risk factor for infection with the epidemic strain of C difficile and restriction of clindamycin led to rapid resolution of outbreaks
These findings provided an ominous warning that acquisition of antimicrobial resistance could play a major part in dissemination of epidemic C difficile strains and highlighted the potential to control outbreaks through restriction of specific antibiotics
Summary
Between 1989 and 1992, an epidemic strain of Clostridium difficile that was highly resistant to clindamycin emerged and caused outbreaks of C difficile infection in several locations in the USA.[1]. These findings provided an ominous warning that acquisition of antimicrobial resistance could play a major part in dissemination of epidemic C difficile strains and highlighted the potential to control outbreaks through restriction of specific antibiotics.
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