Abstract
A novel multi-response pyrazoline-based fluorescent probe 1 was designed and synthesized with a very simple molecular structure, which exhibited high sensitivity for detecting Zn2+ and Cd2+ in ethanol aqueous solution state based on the dissuasion of intramolecular charge transfer (ICT) and chelation-enhanced fluorescence (CHEF) effect. The binding modes of the complexes were determined to have 1:1 complexation stoichiometry and the binding constants were calculated to be 1.284 × 104 M−1 for Zn2+ and 4.313 × 103 M−1 for Cd2+ using the nonlinear curve-fitting method. Zn2+ and Cd2+ sensor have high anti-interference ability. Under optimal conditions, the detection limits were determined to be 0.9274 μM for Zn2+ and 0.8158 μM for Cd2+. Notably, the probe was found to have good biological compatibility and was employed to detect Zn2+/ Cd2+ in living Hela cells.
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