Fluoride and sodium trimetaphosphate (TMP) release from fluoride varnishes supplemented with TMP.

Michele Mauricio Manarelli,Juliano Pelim Pessan,Célio Percinoto,Alberto Carlos Botazzo Delbem

doi:10.1590/1807-3107bor-2016.vol30.0064

Michele Mauricio Manarelli, Juliano Pelim Pessan + Show 2 more

Open Access

https://doi.org/10.1590/1807-3107bor-2016.vol30.0064

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Abstract

This study assessed fluoride (F) and sodium trimetaphosphate (TMP) release into artificial saliva from varnishes containing 0%, 2.5%, and 5% NaF, supplemented or not with 5% TMP. The varnishes were applied on polyester sheets (n = 8/group), and F and TMP released into artificial saliva were measured for up to 24 hours. The amount of F and TMP released were directly related to NaF and TMP concentrations in the varnishes. The highest F release was seen for 5% NaF and 5% NaF + 5% TMP, whereas 5% TMP released the highest amount of TMP. However, the simultaneous addition of NaF and TMP to varnishes significantly reduced the amount of F and TMP released from the products.

Highlights

The addition of phosphate salts to topically applied fluoridated products has been proposed as a method to increase the anticaries effects of such formulations
The present study assessed the release of F and TMP into artificial saliva from varnishes containing NaF and/or TMP over 24 hours
The time-course release of F and TMP from the varnishes into the artificial saliva is shown in Figures 1 and 2, respectively

Summary

Introduction

The addition of phosphate salts to topically applied fluoridated products has been proposed as a method to increase the anticaries effects of such formulations. Sodium trimetaphosphate (TMP) has recently been shown to promote a synergistic remineralizing effect both in vitro[1] and in situ[2] when added to fluoride (F) varnishes. Considering the complex interactions between F and TMP and the scarcity of studies assessing the association between these compounds in varnish formulations, investigating the patterns of the release of F and TMP from these products would be informative, as interactions between NaF and TMP salts, as well as among other varnish components, could potentially affect the efficacy of the products. The present study assessed the release of F and TMP into artificial saliva from varnishes containing NaF and/or TMP over 24 hours

Methods

Results

Conclusion