Abstract
Because of the growing concerns regarding fluoride ingestion by young children and dental fluorosis, it is necessary to develop new dentifrices.ObjectiveThe aim of this study was to evaluate the effect of dentifrices with calcium citrate (Cacit) and sodium trimetaphosphate (TMP) on enamel demineralization. Material and MethodsEnamel blocks (n=70), previously selected through surface hardness analysis, were submitted to daily treatment with dentifrices diluted in artificial saliva and to a pH-cycling model. The fluoride concentration in dentifrices was 0, 250, 450, 550, 1,000 and 1,100 µg F/g. CrestTM was used as a positive control (1,100 mg F/g). Cacit (0.25%) and TMP (0.25%) were added to dentifrices with 450 and 1,000 µg F/g. Surface hardness was measured again and integrated loss of subsurface hardness and fluoride concentration in enamel were calculated. Parametric and correlation tests were used to determine difference (p<0.05) and dose-response relationship between treatments. ResultsThe addition of Cacit and TMP did not provide a higher fluoride concentration in enamel, however it reduced (p<0.05) mineral loss when compared to other dentifrices; the dentifrice with Cacit and TMP and a low fluoride concentration presented similar results when compared to a dentifrice with 1,100 mg F/g (p>0.05). ConclusionsDentifrices with 450 and 1,000 µg F/g, Cacit and TMP were as effective as a gold standard one.
Highlights
Clinical trials have been carried out to check WKH DQWLFDULHV HI¿FLHQF\ RI ORZ ÀXRULGH GHQWLIULFH compared to the conventional 1,100 μg F/g dentifrice2
A recent clinical trial10 conducted for 12 months with children aged from 2 to 4 \HDUV VKRZHG WKH DQWLFDULHV HIIHFW RI D ORZ ÀXRULGH GHQWLIULFH ZDV VLPLODU WR WKH FRQYHQWLRQDO ÀXRULGH dentifrice when used by caries inactive children; in FKLOGUHQ ZLWK DFWLYH FDULHV OHVLRQV WKH ORZ ÀXRULGH dentifrice was less effective than the 1,100 μg F/g dentifrice in controlling the progression of lesions
This study evaluated the effect of two dentifrices supplemented with calcium citrate (Cacit) and TMP on enamel demineralization
Summary
Clinical trials have been carried out to check WKH DQWLFDULHV HI¿FLHQF\ RI ORZ ÀXRULGH GHQWLIULFH compared to the conventional 1,100 μg F/g dentifrice. Reed (1973) found a lower anticaries HIIHFW IRU D ORZ ÀXRULGH GHQWLIULFH ZKHQ FRPSDUHG to the conventional dentifrice. A recent clinical trial conducted for 12 months with children aged from 2 to 4 \HDUV VKRZHG WKH DQWLFDULHV HIIHFW RI D ORZ ÀXRULGH GHQWLIULFH ZDV VLPLODU WR WKH FRQYHQWLRQDO ÀXRULGH dentifrice when used by caries inactive children; in FKLOGUHQ ZLWK DFWLYH FDULHV OHVLRQV WKH ORZ ÀXRULGH dentifrice was less effective than the 1,100 μg F/g dentifrice in controlling the progression of lesions. $QWLFDULHV HIIHFW RI GHQWLIULFHV ZLWK FDOFLXP FLWUDWH DQG VRGLXP WULPHWDSKRVSKDWH fluoride concentration (500 μg/g) and sodium trimetaphosphate (TMP) showed a similar effect to a standard dentifrice. The effect of Cacit on demineralization and remineralization has not been tested yet
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