Abstract
To study HIFU cardiac ablation, florescent imaging was used to monitor in real time the electrophysiology changes of cardiac tissues during focal HIFU ablation. We applied HIFU ablation of AV nodal and ventricular preparations of Langendorff-perfused rabbit heart while monitoring electrical activity in real-time. HIFU energy was applied to ablate the AV node and ventricular tissue of Langendorff-perfused rabbit hearts while monitoring electrical activity in real-time with fluorescent voltage-sensitive dye imaging and surface electrodes. HIFU was generated using a spherical piezoelectric ceramics transducer (diameter 42 mm, F-number 1.2) at 4.23 MHz. When HIFU was applied to ventricular epicardium fluorescent imaging it revealed gradual reduction of the plateau phase and amplitude of the action potential. Subsequently conduction block and cell death were observed at the site of ablation. In our study HIFU produced focal lesions of 0.2–0.8 mm for 10–60-s applications. When HIFU was applied to the AV node, fluorescent imaging and electrograms revealed the development of the AV block.
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