Abstract
The safety of fluorescent nanoparticles (FNPs) that enter the human body through food consumption is uncertain. In this study, the biocompatibility of FNPs derived from roast duck was investigated using pheochromocytoma (PC12) cells and Caenorhabditis elegans. Fluorescent nanoparticles, at concentrations of 1 and 4 mg mL-1, caused an increase in early apoptosis, altered the cell cycle, elevated reactive oxygen species levels, and decreased mitochondrial membrane potential in PC12 cells. Both acute and prolonged exposure to the FNPs enabled them to permeate C. elegans via its food source, accumulating predominantly in the intestine. At concentrations ranging between 0 and 15 mg mL-1, FNPs did not induce mortality in C. elegans but they did affect its growth, reproductive ability, and motor behavior. This study advances the understanding of FNP safety significantly, facilitates risk assessment for foods containing FNPs, and provides valuable guidance to ensure food safety. © 2024 Society of Chemical Industry.
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call