Fluorescent-labeled derivatives of dolichyl phosphate. Analogs of dolichyl phosphate with the 2-aminopyridine residue at the ω-end of the chain*

Abstract

Listen

Translate article

A simple approach to the synthesis of dolichyl phosphate derivatives with a fluorescent label, 2-aminopyridine residue, at the ω-end of the chain was developed. The method includes selective van Tamelen epoxidation of the ω-isoprene unit in dolichyl acetates, transformation of the epoxides to ω-terminal aldehydes, their reductive amination, and phosphorylation of the resulting amino alcohols.