Abstract
Sentinel lymph node procedures for gastric cancer resections using indocyanine green (ICG) linked to Nanocoll outperformed normal ICG but did not provide information on possible lymph node metastasis. Carcinoembryonic antigen targeted fluorescent imaging using SGM‐101 was successful in both pancreatic and colorectal cancer. A large phase III multicentre trial will soon be initiated in colorectal cancer patients.
Highlights
Sentinel lymph node procedures for gastric cancer resections using indocyanine green (ICG) linked to Nanocoll outperformed normal ICG but did not provide information on possible lymph node metastasis
One false‐negative case was observed, which was due to failure of frozen section diagnosis. It still remains unclear if the use of ICG in sentinel lymph node (SLN) procedures has additional value, since it does not give any information on the presence of micrometastases in identified draining lymph nodes
This review outlines the available literature on SLN procedures in gastric cancer using ICG and provides an overview of carcinoembryonic antigen (CEA)‐targeted NIR fluorescence (NIRF) imaging
Summary
Recent studies have indicated that sentinel node biopsy is most relevant in early gastric cancer cases since this subset of patients have low chances of lymph node metastasis.[29,30,31] A recent study by Kinami et al has demonstrated the feasibility of this technique in q72 early gastric cancer cases using ICG.[32] Only one false‐negative case was observed, which was due to failure of frozen section diagnosis It still remains unclear if the use of ICG in SLN procedures has additional value, since it does not give any information on the presence of micrometastases in identified draining lymph nodes.
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