Abstract
To improve the fluorescence properties of covalent organic framework(COF) materials, core-shell SiO2@COF compositewas prepared, in which SiO2 was used as inner substrate, and BMTH (2,5-bis (2-methoxyethoxy) p-phenylhydrazide) and HB (2-hydroxy-1,3,5-phenyltrialdehyde) acted as precursors to construct COFBMTH-HB layer on the surface of SiO2. Compared with COFBMTH-HB, SiO2@COFBMTH-HB composite showed better dispersion property and improvedfluorescence performance under the same experimental conditions. UsingSiO2@COFBMTH-HB as a fluorescence probe, the fluorescence intensity was gradually decreased with the addition of Cu2+, while it was restored by introducing Cys or Hcy, realizing "ON-OFF-ON" fluorescence sensing detection. Other amino acids with fivetimes the concentration of Cys showed little effect on the determination of Cys or Hcy. The SiO2@COFBMTH-HB-Cu2+ probe exhibited ultrahigh sensitivity and good selectivity for the detection of Cys and Hcy, with a detection range of 0.23 to 250.0µM for Cys and 0.31 to 170.0µM for Hcy. The detection limits (LOD = 3 σ/s) were 75 and 104nM for Cys and Hcy, respectively. The system also showed a good recovery and low relative standard deviations in actual sample tests for Cys or Hcy, demonstrating its potential for practical applications.
Published Version
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