Abstract
The native fluorescence characteristics of domperidone in various solvents and at different pH values are reported. The fluorophore is the benzo-1,3-diazolin-2-one group which is also present in the analogous benperidol, droperidol and pimozide molecules from which domperidone is derived; the substituent may therefore be considered as a relatively strong fluorophore; its excitation and emission maxima are little influenced by pH variation. Domperidone can be determined in pharmaceutical preparations by its native fluorescence in ethanol (λ ex = 283 nm ;λ em = 324 nm) and in 0.01 M HCl (λ ex = 284 nm;λ em = 329 mn) with a detection limit of 0.01 μg ml -1.
Published Version
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