Abstract
Fluorescence imagine of retinal microglial cells in rodent and primate under degenerative and regenerative conditions throughout aging
Highlights
Microglia is the most common innate immune cell resident in the central nervous system (CNS). 10–15% of all glial cells is microglia and they are often referred to as the tissue-resident macrophages of the CNS [1,2]
Elevated intraocular pressure (IOP) was maintained for seven weeks and rats were harvested to analyse any possible microglial changes due to elevated pressure in vivo
Elevated IOP in vivo did not lead to an increase in the total amount of microglial cells within the retina (Figure 2A)
Summary
Microglia is the most common innate immune cell resident in the CNS. 10–15% of all glial cells is microglia and they are often referred to as the tissue-resident macrophages of the CNS [1,2]. It is very well known that microglia play a tremendous role in CNS diseases, as microglia process remarkable plasticity and capability of responding swiftly to damage or infection, where they undergo functional and morphological changes as a reaction to neuronal damage and external stimulus [3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40]. In response to injury and degeneration, microglia become activated, change their morphology, proliferate, migrate to the damage sites, modify the expression of enzymes and receptors [16,27,34]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
