Fluid infusion effect of one-hour impact on the acetone bodies and prognosis of the young patients undergoing type 1 diabetes mellitus complicated with ketoacidosis

Abstract

Objective To evaluate the fluid infusion effect of first hour impact on the indexes including blood sugar of the young patients undergoing type 1 diabetes mellitus (T1DM) complicated with diabetic ketoacidosis (DKA).Methods 64 young T1DM patients conplicated with DKA were randomly divided into the observation group and control group (n=32 for both groups); the former 32 cases in the first hour was given oral or stomach tube injection liquid with 1000 ml,and at the same time added express intravenous fluid infusion for 1000 ml and given micro pump control insulin injection speed.The control group was only given 1500 ml fluid via intravenous infusion.We compared the blood sugar,blood ketone and blood gas analysis results before and after first hour fluid infusion.Results Two groups of patients before the rescue of blood sugar,blood ketone indices showed no statistical difference (P＞0.05); the two groups after treatment with the above specifications were changed significantly (observation group before and after blood sugar was t=5.828,P=0.006; blood ketone was t=2.164,P=0.023.Control group blood sugar compared as t=4.112,P=0.013; blood ketone was t=2.037,P=0.033).1 hour after two groups' blood sugar,blood ketone,pH and PaCO2 were statistically significant (P=0.025,0.032,0.037 and 0.034 respectively),the observation group' s blood sugar,blood ketone and PaCO2 were lower (P ＜ 0.05),and the pH higher (P ＜ 0.05).In the prognosis of two groups,shock,the incidence of kidney failure were not statistically different.Conclusion The method which combines oral way with intravenous infusion in the first hour is proved to be more effective on reducing the blood glucose and ketone for the young patients undergoing T1 DM complicated with DKA. Key words: Type 1 diabetes mellitus (T1DM); Complications; Diabetic Ketoacidosis (DKA); Fluid infusion; Blood gas analysis