Abstract
Fluid shifts and electrolyte changes were studied in skeletal muscle and in myocardium of normal male rats weighing 150–450 g and in rats with cardiac hypertrophy experimentally produced by subdiaphragmal aortic constriction. Extracellular fluid volume was measured by means of 35S-sulfate and was found to increase in all parts of the heart and in skeletal muscle as rats grew from 150 to 300 g. Maximal values for sulfate space were reached in the 250–300 g group and then they decreased as the rats continued to grow from 300 to 450 g. Significant increases (p < 0.05) in sulfate space and sodium concentration of the left and right ventricles were found to occur within 24 h after aortic constriction whereas a significant increase in cardiac mass (p < 0.05) occurred only after 2 days. The increases became very pronounced (p < 0.001) by 10 days, after which both sulfate space and electrolyte concentration returned to within the normal range. Since these transient increases in sulfate space occur prior to and during very rapid growth in both normal muscle and following aortic constriction, a relationship is suggested.
Published Version
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