Abstract
Novel chemiluminescence (CL) reaction systems were established for the determination of anticancer drugs, including adriamycin (ADM), hydroxycamptothecin (HCPT), mitomycin (MMC), and fluorouracil (5-FU). The formaldehyde-sensitized CL emission mechanism was developed for four systems by comparing the fluorescence emission and CL spectra. For ADM-KMnO4-HNO3, HCPT-KMnO4-H2SO4, MMC-KMnO4-HNO3, and 5-FU-KMnO4-HCl systems, the illuminant was a singlet state bimolecule oxygen, 1O2 1O2(1Δg 1Δg), which was formed from 1O2 (1Δg) produced in the reaction system. The illuminant emits CL spectra at 539 or 549 nm. The presence of formaldehyde can sensitize CL emission because it may accelerate the generation of 1O2 (1Δg). The optimum conditions for the CL emission were chosen. The relationships between the relative CL intensity and the concentration of the studied analytes are linear with the correlation coefficients in the range of 0.9959–0.9989. The proposed four enhanced CL systems provide a good linearity, a high sensitivity, precision, and the potential capability for the determination of anticancer drugs in biological samples.
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