Abstract
A flow injection spectrophotometric procedure with symmetric merging zones for dipyrone determination in pharmaceutical formulations is proposed. The determination is based on the formation of a blue complex (monitored at a wavelength of 642 nm) yield in the complexation reaction of dipyrone with Fe(III) in acid medium. Under optimum conditions, a calibration curve was obtained from 3.5 to 281 mg L−1 with a detection limit of 2.8 mg L−1 and the samples throughput was 80 h−1. The analytical results obtained for commercial formulation samples by applying the proposed method were in good agreement with labeled values and those obtained by a comparative procedure at a 95% confidence level.
Published Version
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