Abstract
A flow injection spectrophotometric procedure is proposed for determining adrenaline in pharmaceutical formulations. In this work, the adrenaline in acetate buffer reacts with a solid-phase reactor containing lead(IV) dioxide immobilized in a polyester resin and the adrenochrome yielded was continuously monitored at 486 nm. The analytical curve was linear in the adrenaline concentration range from 0.1 to 0.8 mmol l −1 with a detection limit of 8×10 −3 mmol l −1. Recoveries of 96.5–105% and relative standard deviation of 0.2% for a solution containing 0.4 mmol l −1 adrenaline ( n=10) were obtained. The analytical frequency was 130 determinations per hour and the results obtained for adrenaline in pharmaceutical formulations using this procedure and those obtained using a pharmacopoeia procedure are in agreement at the 95% confidence level.
Published Version
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