Abstract
Chemiluminescence (CL) of permanganate system in the presence of polyphosphoric acid (PPA), ethanol and Tween 60 was investigated and implemented using flow-injection analysis (FIA) to determine cinnarizine (C) in pharmaceutical preparations. Five hundred microliter samples were injected and the sample throughput was 130 h −1. Preliminary experiments identified Tween 60 as the surfactant of choice, improving the detection limit of the CL system 20-fold. Optimum CL signals were given using 7.5×10 −4 mol l −1 potassium permanganate in 0.02 mol l −1 polyphosphoric acid as the oxidant stream and a carrier stream of 10% (v/v) of ethanol in aqueous 1.5×10 −3 mol l −1 Tween 60 with a total flow rate of 7.6 ml min −1. The calibration graph was linear over the range 0.5–6.0 μg ml −1 ( r=0.9963, n=7). The detection limit (3 σ) was 18 ng ml −1 and the percentage recovery of spiked tablet solutions was 98.4–100.2.
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