Abstract
Objectives Mature B-cell neoplasms consist of a diverse group of disorders with distinct clinical presentations, pathology, and outcomes. This article aims to describe the clinical, morphological, and flow cytometry immunophenotypic findings of 30 diagnosed patients with B-cell lymphoproliferative disorders (B-CLPDs) in a tertiary care hospital in Sri Lanka. Material and Methods A descriptive cross-sectional study, including 30 cases of BCLPDs diagnosed over a period of 6 months, was analyzed. Diagnosis of BCLPDs was made by morphology of peripheral blood, bone marrow, and the immunophenotypic analysis by multiparametric flow cytometry on bone marrow aspirates or peripheral blood. Results CD5-/CD10- BCLPD with negative hairy cell markers was the most common subtype (30%), followed by chronic lymphocytic leukemia (CLL) at 26.6% and mantle cell lymphoma (MCL) at 20%. Persistent lymphocytosis was the most frequent clinical finding across BCLPD cases, while hepatomegaly was common in the cases of the CD5-/CD10- BCLPD with negative hairy cell markers. This category appears distinct from other known subtypes like splenic marginal zone lymphoma (SMZL) or hairy cell leukemia (HCL), suggesting a unique clinical profile. Conclusion The study highlights distinct immunophenotypic and clinical profiles across BCLPD subtypes, with CD5-/CD10- BCLPD subtype with negative hairy cell markers emerging as the most prevalent and showing unique marker patterns that may aid in differential diagnosis.
Published Version
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