Abstract

Overview Overview of the 5-Lipoxygenase Pathway, Jesper Z. Haeggstroem and Bengt Samuelsson Leukotriene Biochemistry 5-Lipoxygenase and 5-Lipoxygenase-Activating Protein, Jilly F. Evans Leukotriene C4 Synthase: A Pivotal Enzyme in the Biosynthesis of Cysteinyl Leukotrienes, John F. Penrose and K. Frank Austen Leukotriene A4 Hydrolase, Jesper Z. Haeggstroem Leukotriene Export in Human Leukocytes, Bing K. Lam Cell Biology of the Leukotrienes Pathways of Leukotriene Metabolism in Isolated Cell Models and Human Subjects, Robert C. Murphy and Pat Wheelan Cell Biology of the 5-Lipoxygenase Pathway: Amplification and Generation of Leukotrienes and Lipoxins by Transcellular Biosynthesis, Timothy D. Bigby, Bruce D. Levy, and Charles N. Serhan Physiological Actions of the Leukotrienes Leukotriene Receptors: Incompletely Defined Targets for Treatment of Asthma and Inflammation, Sven-Erik Dahlen Physiological Effects of the Leukotrienes in Humans, Neil C. Barnes and Lewis J. Smith Recovery of Leukotrienes Analysis of Leukotrienes and Lipoxins, Graham W. Taylor Measurement of Leukotrienes from Human Biological Fluids, Jay Y. Westcott and Ian K. Taylor Leukotrienes in Asthma Cysteinyl-Leukotriene Receptor Antagonism and 5-Lipoxygenase Inhibition in Asthma, S. M. Shuaib Nasser and Tak H. Lee Leukotriene Receptor Antagonism and Synthesis in Chronic Stable Asthma, Elliot Israel and Jeffrey M. Drazen Specific Drug Products Montelukast-An Antileukotriene Treatment for Asthma: Changing the Asthma-Treatment Paradigm, Beth C. Seidenberg and Theodore F. Reiss Pranlukast-The First Orally Active Cysteinyl Leukotriene Receptor Antagonist Marketed for the Treatment of Asthma, Jeffrey W. Dubb and Anthony S. Rebuck Zafirlukast, Catherine M. Bonuccelli and Trevor J. C. Higgins Zileuton: The First Leukotriene Synthesis Inhibitor for Use in the Management of Chronic Asthma, Louise M. Dube, Linda J. Swanson, Walid Awni, Rachel F. Ochs, Randy L. Bell, and George W. Carter Antileukotrienes in the Management of Asthma, Paul M. O'Byrne

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