Abstract
Five new phenolic compounds rynchopeterines A–E (1–5), in addition to thirteen known phenolics, were isolated from Blaps rynchopetera Fairmaire, a kind of medicinal insect utilized by the Yi Nationality in Yunnan Province of China. Their structures were established on the basis of extensive spectroscopic analyses (1D and 2D NMR, HR-MS, IR) along with calculated electronic circular dichroism method. Rynchopeterines A–E (1–4) exhibited significant antioxidant activities with IC50 values of 7.67–12.3 μg/mL measured by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. Besides, rynchopeterines B (2) and C (3) showed mild cytotoxicity against tumor cell Caco-2 and A549.
Highlights
Insects have long been utilized as medicines in the world, especially in China
3-hydroxytyrosol group according identified in its NMR spectra [18], which was connected to C-8 in 3-hydroxytyrosol group according to to Theabsolute absoluteconfiguration configurationofofC-2
The results indicated that the ethylscavenging acetate fraction is abundant antioxidant ingredients, while the 50 values values of petroleum ether (PE)
Summary
Insects have long been utilized as medicines in the world, especially in China. Insects make up the largest and most diverse group of organisms on earth, and could serve as a vast potential medicinal resource. It was reported that a huge variety of chemical substances with potent biological activities which might have use as lead compounds in drug discovery have been isolated from insects in recent years [3]. Blaps rynchopetera Fairmaire belongs to the family Tenebrionidae (Coleoptera), and is a kind of insect that has long been utilized as a folk medicine by the Yi Nationality in Yunnan Province of China. This insect is effective in the treatment of cough, gastritis, and various cancers [4].
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