Abstract
Five new meroterpenoids, clavipols A–B (1–2) with a 12-membered ether ring and clavilactones G–I (3–5) having a 10-membered carbocycle connected to a hydroquinone and an α,β-epoxy/unsaturated lactone, were obtained from the fruiting bodies of the basidiomycete Clitocybe clavipes. Their structures were determined by comprehensive analysis of their spectroscopic data, and the absolute configuration of 1 was established by quantum chemical calculations of electronic circular dichroism (ECD). All the isolated compounds (1–5) were tested for their cytotoxic activity against three human tumor cell lines (Hela, SGC-7901, and SHG-44) in vitro after treatment for 48 h. Compound 4 exhibited moderate cytotoxic activity against Hela and SGC-7901 tumor cell lines, with IC50 values of 23.5 and 14.5 µM, respectively.
Highlights
Secondary metabolites from fungi have attracted the attention of chemists, pharmacologists, and biologists because of their unique chemical structures and potential biological activities [1,2,3].Meroterpenoids are defined as compounds partially derived from terpenoids [4]
This paper reports th five isolated new meroterpenoids, as well as their cytoto
This paper reports basidiomycete C. clavipes led to the isolation of five new meroterpenoids, clavipols A–B (1–2) and the isolation and structural elucidation of thereports five isolated new meroterpenoids, as well asoftheir clavilactones
Summary
Secondary metabolites from fungi have attracted the attention of chemists, pharmacologists, and biologists because of their unique chemical structures and potential biological activities [1,2,3].Meroterpenoids are defined as compounds partially derived from terpenoids [4]. Fungal meroterpenoids, including pyripyropene A [5], arisugacins [6], and territrems [6], have been reported to have novel and fascinating chemical structures. They have diverse structural skeletons and show biological activity, such as antitumor [7], anti-inflammatory [8], antioxidant [9], antibacterial [10], and antifungal [10] activities. The meroterpenoids clavilactones A–E have been reported to have potent pharmacological activity, such as antifungal activity and inhibition of protein tyrosine kinases [13,14].
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